Overlap of regulated transcripts in pairs of studies for each tissue type was evaluated by comparing probe IDs of DE genes from each pair of studies (Figure 2). In PFC, there was significant overlap between Chronic and CI and between CI and LPS, but no overlap for the other pairs of treatments. In liver, all pairwise comparisons showed an overlap of DE genes that was significantly greater than expected by chance for all study comparisons (Figure 2). Moreover, the majority of shared DE genes tend to be regulated in the same direction in both studies (Figure 2). LPS and CI treatments displayed the most similarly regulated transcripts in PFC (78 transcripts) and in liver (213 transcripts).
