Chunk #12 — Methods

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Dosage transmission disequilibrium test (dTDT) for linkage and association detection.

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The dosage-TDT that we have developed in this study is applied on these trio pedigrees using their inferred dosage probabilities. By incorporating the family linkage information into the GWAS data, we can potentially have higher power to detect association between our genotypic markers and the disease susceptibility alleles.