Chunk #17 — Results — Correcting for confounding effects on gene association scores in the absence of genotype data

Source

Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.

Embedded

yes

Text

For the current study we used the regression-based correction, as it seems to behave equally well for different GWA studies (e.g. DGI study and DIAGRAM+ meta-analysis; see Figure S4A, S4B), while the modified Sidak's correction (in particular its correction for dependency between SNPs) may need to be adjusted for specific studies, e.g. due to different SNP densities (see Figure S4C, S4D). In any case, we later show that all GSEA results presented in this work are robust relative to the correction method used.