In summary, we explored episodic memory capacity of the healthy elderly adults using ReHo analysis of resting state fMRI data, providing vital insights into our understanding of brain activity of regional coherence and its cognitive implications. Our study indicates that ReHo, a feasible and easily applied approach, can be employed to characterize the neural correlations of traditional list-learning test results. Furthermore, the neural mechanism of memory consolidation has received increasing attention, and our findings reveal the possible relationship between the DMN and memory consolidation during wake for the first time. We also demonstrated that DMN activity measured with ReHo analysis can be used as a way to identify biomarkers for memory decline and neurodegenerative disease.