biological significance of these findings, however, is that none of the transcription factors whose binding motif was over-represented in the candidate gene promoters was differentially expressed in the brain of LAFT and HAFT mice. Moreover, there was a particularly poor overlap between the lists of over-represented transcription factors generated by these three studies, although they were all based on gene expression profiling in the whole brain of HAFT and LAFT mice, thereby challenging the role these transcription factors may play as key coordinators of gene expression patterns predisposing to high vs low acute functional tolerance to ethanol.
