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Chunk #18 — Results — Interaction between individual recent life event subscales and the 5-HTTLPR genotype on current depressive symptoms

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Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms.
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RLE-financial is a three-question subscale of RLE with items about financial difficulties, unsuccessful attempts to find a job or being fired. In all three population samples (Budapest, Manchester and combined) association of the RLE-financial score in interaction with the 5-HTTLPR polymorphism was significant by using additive or recessive model of heritability. These significances survived the test for false discoveries with one exception in the Manchester sample (additive model P=0.0481) showing the replicability of the result in the two population subsamples. P-values of the significant interactions are presented in Tables 2, 3 and 4 and Figures 1b, c and d.