Studies have shown a degree of shared genetic liability for different psychiatric disorders, likely a result of multiple factors including genetic pleiotropy, diagnostic overlap, comorbid disease, or disease progression. To initially assess shared genetic risk across psychiatric disorders we present p-values across five psychiatric traits (Schizophrenia, Bipolar Disorder, Neuroticism, Depressive symptoms, and Subjective Well-Being) for SNPs with p-values less than 1×10−5 in the MDD meta-analysis (Supplementary Table 11)21. The MDD SNPs showed the highest degree of overlap (smallest p-values) in the Schizophrenia dataset, followed by Neuroticism, with less replication in the Bipolar, Depressive Symptoms, and Subjective Well-being phenotypes. Schizophrenia and Bipolar GWAS are from the publicly available PGC datasets12,22 while corresponding p-values for Neuroticism, Depressive Symptoms, and Subjective Well-being were provided by the bior The lack of correlation with SSGAC depressive symptoms self-report data may arise from the latter considering only depressive symptoms experienced during the previous two weeks-versus lifetime major depression in the primary cohorts. Conversely, the trait measure of neuroticism has previously been show to overlap with major depression, consistent with our results.
