The evolutionary and annotation properties of cis regulatory associations are very relevant since the density of the phase II HapMap allows for a fine-scale analysis of the association signal. The vast majority of detected cis regulatory effects map very close to the TSS and are enriched in regions of high sequence conservation. This information provides a useful framework to search for cis regulatory variants in the human genome and suggests that most of the large effect variants are in the genic and immediate intergenic regions. The association data will become available at the Ensembl web site in the October 2007 as Distributed Annotation System (DAS) tracks to enable browsing and downloading.
