The number of differentially expressed genes differed greatly among the six brain regions. At 10% FDR, we found that 16, 28, 12, 15, 8, and 27 genes were significantly regulated in the amygdala, hippocampus, NA, PFC, striatum, and VTA, respectively (Table 1). In the amygdala, several genes involved in mitochondrial function, specifically electron transport, were upregulated, including Atp5j, Mt-co1, Mt-cyb, and Mt-nd6. Multiple genes involved in transcription also were modulated, such as chromodomain helicase DNA-binding protein 6 (Chd6), zinc finger protein CCHC domain containing 12 (Zcchc12), and zinc finger protein interacting with K protein 1 (Zik1). We also observed regulation of protein modification- and degradation-related genes, which included chaperonin subunit 5 (Cct5) and proteasome (prosome, macropain) activator subunit 4 (Psme4). In the hippocampus, mitochondrial electron transport genes were upregulated; e.g., Atp5j, Mt-co1, Mt-nd2, and Mt-nd4, as were several genes involved in protein translation, such as acidic ribosomal phosphoprotein P0 (Arbp), eukaryotic translation initiation factor 3, subunit 8 (Eif3s8), and tumor protein, translationally controlled 1 (Tpt1). We also observed alterations in the expression of genes related to signal transduction, such as CD24a (Cd24a), neurotrophic tyrosine kinase receptor type 2 (Ntrk2), and polo-like kinase 2 (Plk2).
