There is increasing awareness of the modulation of function of membrane proteins by their interaction with lipids. This model of proteins moving between different lipid microenvironments during AFT might include the effects of ethanol on multiple ethanol responsive proteins in addition to SLO-1. For instance, ethanol treatment inhibits localization of the proteins Lck, ZAP70, LAT and PLCγ1 to lipid rafts in T lymphocytes [15]. Another intriguing candidate for a protein whose function is may be modulated by its location in rafts is H-ras, which is known to be involved in the dynamic response of NMDA receptors to ethanol [32]. In its inactive form, H-ras resides in lipid rafts, and when activated, it must move out of rafts to efficiently activate its target Raf [33].
