However, it is not as simple as a pure equivalence between reduced anatomical connectivity and reduced functional connectivity. Indeed, in a very reproducible way, bilateral functional connectivity is found to be increased.47-51 This is especially true between the two frontal lobes despite abnormal or reduced colossal fibers. It can be argued that, whereas the first anomaly is a primary deficit, the increased functional connectivity between the frontal lobes could be a secondary abnormality, eg, a compensator}' recruitment for better control over the posterior instrumental regions.38
