At each visit, participants were given additional medication and asked to return any unused medication. We computed the percentage of medication each participant used by subtracting the amount of medication the participant returned from the amount of medication given to the participant and then dividing that by the total amount of medication given to the participant. On average, participants used approximately 77% of the medication given out over the course of the study (placebo = 75%, patch = 86%, bupropion = 85%, lozenge = 67%, bupropion + lozenge = 77% and patch + lozenge = 74%). A one-way ANOVA revealed significant differences in the amount of medication used by treatment condition, F(5, 1187) = 17.64, p < .001. Post-hoc Tukey tests revealed that individuals in the lozenge condition used significantly less medication (67% of the medication given) than individuals in any of the other treatment conditions (p’s ranged from .03 to less than .001).
