These evaluations focused on 235 probands from the San Diego Prospective Study (SDPS) who participated in all follow-up evaluations at 15 years (T15), 20 years (T20), 25 years (T25) and 30 years (T30) after their baseline (T1) alcohol challenge protocol at about age 20 (Schuckit and Smith, 2011). As shown below, these men represent the large majority of the 65% of subjects who were eligible to date for follow-up at the 30 year epoch in the prospective study. Subjects had originally been chosen as matched pairs of men who were family history positive and negative for AUDs from among respondents to questionnaires distributed each year to students and non-academic staff at our university between 1978 and 1988. Drinking but not alcohol-dependent 18-to-25-year-old White males with no lifetime substance dependence and no significant current medical or psychiatric disorders were asked to participate in an alcohol challenge to evaluate their LR to alcohol. Subjects received oral alcohol (e.g., 0.75 ml/kg as a 20% solution with a sugar free carbonated beverage with a peak BAC of ~.06 g/dL) and a placebo session, with
