Baseline differences in adult neurogenesis in the dentate gyrus exist among species. Most notably, there is greater production of new neurons in rats compared to mice; these neurons differentiate faster and are more functionally significant in the hippocampus of rats than mice (Snyder et al., 2009a). As mentioned above, acute restraint stress decreases cell proliferation in rats but increases cell proliferation in mice (Bain et al., 2004). Species differences in adult neurogenesis may alter the effects of stress on adult neurogenesis.
