of the 1832 chromosomes (0.27%) in OD cases; the minor allele of the second RV rs116628628 occurred in 26 of the 6334 chromosomes (0.41%) in OD controls, and 13 of the 1838 chromosomes (0.71%) in OD cases; the minor allele of the third RV rs61737326 occurred in 58 of the 6352 chromosomes (0.91%) in OD controls, and 8 of the 1834 chromosomes (0.44%) in OD cases. Therefore, two of the three rare variants in DISC1 were protective, and another was deleterious. These three RVs in DISC1 were independent of each other, with only one AA subject carrying two different minor alleles (rs139667828 and rs61737326) and no subjects carrying three different minor alleles. In EAs, because each of the three DISC1 RVs was observed only once, we could not test for association (Of course, other RVs in DISC1 may affect OD risk in EAs). For GRIN2B, only one RV (rs146792012) was studied. In AAs, its minor allele was not observed in any of the 6320 chromosomes in OD controls, but was found in 3 of the 1814 chromosomes (0.17%) in OD cases. This RV was also observed at a low frequency in EAs, but its association with OD was not statistically
