We observed that patients exhibited increased BOLD signal in response to alcoholic beverage cues compared to non-alcoholic beverage cues in the bilateral posterior cingulate cortex (PCC), right angular gyrus, left pregenual (pgACC) and right dorsal anterior cingulate cortex (dACC), left dorsomedial prefrontal cortex (dmPFC), left orbitofrontal cortex (OFC), right occipitotemporal gyrus (OTG), left angular gyrus (AG), right hippocampus (HIP), left parahippocampal gyrus (PHC), left amygdala (AMG), left nucleus accumbens (NAcc), right ventral striatum (VS), left thalamus and bilateral cerebellum. The left anterior insula (AIC) showed decreased BOLD signal in response to alcoholic beverage cues compared to non-alcoholic beverage cues. The results are displayed in Fig. 1 and the corresponding p-values are displayed in Table 2.Table 2Regions of activation in which alcohol related cues elicited greater activation than non-alcohol related cues (means p < 0.001 uncorrected, Cluster size >60 voxels).Regions left/right t-scorePeak-level coordinatesCluster sizexyzPosterior Cingulate CortexL&R10.62−6−58−24142CerebellumL&R8.07−4−62−16Dorsal Medial Prefrontal CortexL4.75−124238175pregenual Anterior Cingulate CortexL5.26−106014115Orbitofrontal CortexL5.03−3234−882OccipitalTemporal GyrusR6.6654−64−4488ThalamusL6.62−18−18288Angular GyrusL4.66−347-7032186HippocampusR5.4520−24−6162Parahippocampus,L5.31−24−36−12363AmygdalaL4.81−20−2−20Dorsal Anterior Cingulate CortexR6.7441428117Nucleus AccumbensL5.12−40−6378Ventral StriatumR5.0116140InsulaL−4.22*−402−666Coordinates are reported in Montreal Neurological Institute (MNI) coordinate.*Means p = 0.001.
