Table 3 summarizes the genetic loci that have substantial statistical support for association with T2D as of the summer of 2008. As shown, some of these loci were identified through non-GWA approaches. Others emerged out of single GWA studies combined with data from several replication datasets; while a number of them have emerged only recently as the result of meta-analysis of several GWAs and replication datasets, as described above. A common feature is that rarely has a single study been able to reach genome-wide significance for specific loci. This has required the combination of data from several studies, GWA scans and focused replication efforts.
