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Chunk #14 — Results — Association between miRNA and target mRNA expression

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MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.
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these are thought to be more likely to have a gene-regulatory function [38]. Thus, we performed 248 GSE analyses. In abdominal adipose tissue 55 out of 248 (22%) miRNAs were found to have a significant (FDR adjusted p-value<0.05) association with their predicted conserved target mRNAs (Table S7). In gluteal adipose tissue, the same analyses revealed that 23 out of 248 (9%) of miRNAs had a significant association with their predicted conserved target mRNAs (Table S8). Eight of the miRNAs that showed significant associations with their target mRNAs, were common between the two tissue types: hsa-miR-181a, hsa-miR-186, hsa-miR-30a, hsa-miR-141, hsa-miR-30d, hsa-miR-590-3p, hsa-miR-128 and hsa-miR-340 ( Figure 5A ).