Hierarchical clustering was performed on the GWAS t-statistics from the discovery data set results using independent SNPs clumped from the TATES results (clumping parameters: significance threshold for index SNP = 0.01, significance threshold for clumped SNPs = 0.01, r2 = 0.25, physical distance = 1 Mb; Extended Data Fig. 6b). Regions with the strongest genetic similarity were grouped together based on the strength of their pairwise correlations. The results were represented visually using hierarchical clustering with default settings from the gplots package (version 2.12.1) in R.
