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Chunk #12 — BACKGROUND — Hypothesized Role of the Glucocorticoid Receptor Gene (NR3C1) in Regulating Response to the Fast Track Intervention

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Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
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stressors, and has been implicated in child and adult manifestations of externalizing psychopathology (McBurnett et al., 1991; Hawes, Brennan, & Dadds, 2009; Lopez-Duran et al., 2009; Savitz, Lucki, & Drevets, 2009; Stadler, Poustka, & Sterzer, 2010; van Zuiden et al., 2011; Fardet, Petersen, & Nazareth, 2012). Particularly relevant to the current study is evidence that children exhibiting low cortisol reactivity to experimental challenge respond less favorably than high cortisol-reactive children to an intervention designed to reduce disruptive behavior (van de Wiel et al., 2004).