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Chunk #18 — Results — Measurement-Error-Corrected Estimator for PGI Regressions

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Resource profile and user guide of the Polygenic Index Repository.
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Typical research with a PGI involves running a regression with the PGI as an explanatory variable and reporting results in units of standard deviations of the PGI. This approach, however, has two shortcomings. First, it is often unclear how to interpret these units, which depend on the amount of measurement error. Second and relatedly, the effect sizes are not comparable across PGIs that differ in their amount of measurement error.