Thus, we observed that alcohol differentially affects transcripts with specific 3’UTRs, similar to its differential regulation of transcripts with distinct exonal concatenations (ALCOREX vs STREX) located in the protein coding sequences (CDS). These data led us to hypothesize that association of specific CDS exons with specific 3’UTRs is not coincidental. Indeed, we observed that CDS exons associate with 3’UTRs in a deliberate manner: STREX exon was associated with both 3’UTRs in very similar amounts, while ALCOREX exon was exclusively associated with 3’UTR-2.1 (Figure 5F).
