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Chunk #10 — Materials and Methods — SNP selection

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Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.
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The candidate SNPs were identified through review of primary literature, focusing on SNPs that have been previously associated with alcohol dependence and CD in order to replicate previous findings (Dick et al. 2006; Edenberg et al. 2004; Covault et al. 2004; Lappalainen et al. 2005; Fehr et al. 2006; Soyka et al. 2008; Covault et al. 2008; Enoch et al. 2009; Bierut et al. 2010; Philibert et al. 2009; Ittiwut et al. 2012; Li et al. 2013; Lind et al. 2008; Sakai et al. 2010). Two of the most well-replicated SNPs for alcohol dependence, rs279858 and rs279871, were chosen in addition to 3 other SNPs from GABRA2: rs567926, rs279845, and rs9291283. These three later SNPs have been associated also with alcohol dependence in the literature (Edenberg et al. 2004; Covault et al. 2004; Fehr et al. 2006; Soyka et al. 2008; Covault et al. 2008; Bierut et al. 2010; Philibert et al. 2009; Li et al. 2013; Lind et al. 2008), but with less support than rs279858 and rs279871. Rs567926, rs279845, and rs9291283 were not in high linkage disequilibrium (LD)