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Chunk #20 — The Future of Cross-Disorder Genomics

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Shared genetic architecture across psychiatric disorders.
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subgroups within MDD (Howard et al., 2020), but this remains to be tested across other disorders. Extraordinary efforts are also underway to collect symptom level data for individual disorders. In addition, electronic health records (EHRs) are becoming an increasingly utilized resource that can be used to link genomic data and population-level medical registries that include information on both a wide range of psychiatric traits and other diseases or outcomes (Smoller, 2018). Indeed, a number of initiatives have been created with the explicit purpose of capitalizing on EHR and genomic data, including the eMERGE network (Gottesman et al., 2013), the PsycheMERGE consortium (Zheutlin et al., 2019), the NIH “All of US” program (All of Us Research Program, 2019), the Genomic Aggregation Project in Sweden (GAPS; Bergen & Sullivan, 2017), the Danish Biobank Register (Agerbo et al., 2015), and the Nord Trondelag Health Study (HUNT; Krokstad et al., 2013).