of intron 7 (Supplementary Fig. 8). Suppression of furin_a led to a 24% decrease in head size (Fig. 3A, B); this observation was replicated in CRISPR/Cas9 mutants (Supplementary Fig. 8) and in embryos injected with a second sbMO targeting exon 5 (data not shown) Importantly, expression of human FURIN mRNA could rescue the phenotype induced by either morpholino, providing evidence for specificity (Supplementary Fig. 8).
