et al. findings. Overall by incorporating functional annotations we see a marked improvement in fine-mapping resolution across all four traits as indicated by a reduction in the 90% confidence sets relative to PAINTOR models with no annotations of 19.0%, 34.9%, 50.6%, and 24.2% for HDL, LDL, TC, and TG, respectively (Table 7). This corresponds to approximately an average reduction of 17.5 to 13.5 SNPs per locus across the four traits.
