While some PTPs stimulate NF-κB activation, other PTPs negatively regulate NF-κB activation. For instance, PTEN, a tumor suppressor with phosphatase activity is known to inhibit NF-κB activation [79]. Recently, Chew et al., [80] found that WIP1, a Ser/Thr PP2C family of phosphatases act as a negative regulator of NF-κB activation. Overexpression of WIP1 was associated with decreased NF-κB activation, whereas WIP1 knockdown resulted in increased NF-κB activation. The group further showed that WIP1 target Ser536 of the p65 subunit of NF-κB.
