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Chunk #9 — METHODS — Study 2

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Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.
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Participants were European-ancestry smokers randomized to either bupropion or placebo and all participants received behavioral counseling treatment concurrently. Ancestry was assessed by self-report of “White, non-Hispanic” racial/ethnic heritage confirmed by ancestry-informative markers. Treatment consisted of bupropion (150 mg/day for the first 3 days, followed by 300 mg/day), or matching placebo, for 10 weeks and counseling which took place at one of two sites (see Lerman et al. (37) for more details).