distinguishing those who will have an acute infection and those who will develop a persistent one.[42] We hypothesize that Bcl-2 upregulation may be assisted by the putative effect of the rs4878712-G allele on reducing FBXO10 expression, providing less SCF E3 ubiquitin ligase to tag Bcl-2 for degradation and higher basal BCL2 expression. Our combination of gene expression evidence and extant literature is consistent with a plausible mechanism linking rs4878712 to acute response to HIV exposure (Fig. 4).
