The analysis did not produce any genome-wide significant findings, the highest P value reaching 9.08 × 10−7. Nineteen SNPs showed interaction association P values below 10−5 in the presence of main genetic effects (at P ≤ 10−5), of which five showed association under two genetic models (Table 5). Only two findings were related to maternal criticism. Most of the genes interacting with maternal warmth clustered in three distinct regions on chromosomes 6, 11 and 13. The regions on chromosomes 6 and 11 fall into genes, KIF6 and PIWIL4, respectively. The region of 58 kb on chromosome 13 includes 8 association findings for 4 unique SNPs, and although it does not contain genes, it shows extensive LD extending proximally to the SLC46A3 gene, the function of which is unknown. Interestingly, the KIF6 gene has repeatedly been shown to respond to environmental stimuli (Iakoubova et al. 2008b; Iakoubova et al. 2008a; Shiffman et al. 2008). In the referenced studies, a coding variant in KIF6 altered the response to statins in cardiovascular disease. The gene’s role in moderating the influence of mother’s warmth
