factor, OR = 1.27, p < .001; and alcohol abuse factor OR = 1.21, p < .001). In step c′, the associations between CADM2 and lifetime smoking and risky alcohol use factors were attenuated when including the mediator (p = 1.01e‐22 to 1.51e‐18 and 5.84e‐13 to 5.05e‐09, respectively), suggesting partial mediation by risk‐taking proneness. The association between tobacco (ab)use and CADM2 was enhanced (p = 4.34e‐05 to 9.14e‐07) when controlling for risk‐taking proneness, which suggests that there was no mediation effect.