The genomewide non-parametric linkage results for AAs and EAs are presented in Figure 1. The strongest linkage signal was identified on chromosome 8p21.1 at 54.9 cM (lod=2.9, pointwise P = 0.00013, empirical genomewide P = 0.097) in AAs, and weak linkage evidence was detected at the same location in EAs (lod=0.62, pointwise P = 0.05). We identified a second genomewide suggestive linkage peak in AAs on chromosome 14 with a peak lod of 2.26 at 89.9 cM, though no linkage evidence was detected at this peak region in EAs. In EAs, only one region showed genomewide suggestive linkage on chromosome 7 at 107 cM (lod=1.85), where weak linkage signal was observed in AAs (lod=0.19). The locations and values of these suggestive linkage peaks did not change when analyses were repeated using different r2 values to group SNPs into clusters.
