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Chunk #58 — Future Considerations to Address Sex/Gender Disparities — Hormones and Neurosteroids

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Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.
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in boys. Findings were not significant for girls even when controlling for contraceptive use (Peters et al., 2015). A subsequent study by the same group found no SG differences in amygdala-OFC connectivity or alcohol use in a larger sample of over 200 adolescents and young adults who also drank alcohol (Peters et al., 2017); although, this study did not examine the modulating effect of sex hormones. In healthy, adult premenopausal women, however, testosterone administration reduced functional coupling of the amygdala and OFC, suggesting that testosterone may produce alterations in regulatory control over the amygdala (van Wingen et al., 2010).