mg/kg of methOEA (Fig. 6D: time–treatment interaction, F(28,182)=3.06, p<.01). In contrast, WY14643 did not alter the effects of cocaine on dopamine levels in the nucleus accumbens shell. Basal levels of dopamine in dialysates, expressed as mean fmoles/10 μL sample ± SEM, did not differ between groups prior to injections (Fig. 5A,C; vehicle+nicotine: 31.2±5.2; WY14643 40 mg/kg+saline: 31.8±5.2; WY14643 20 mg/kg+nicotine: 30.8±4.5; WY14643 40 mg/kg+nicotine: 36.0±5.9; MK886+vehicle+saline: 41.0±6.0; MK886+WY14643 40 mg/kg+nicotine: 32.0±4.8; Fig. 5B,D; vehicle+nicotine: 30.8±2.9; methOEA 5 mg/kg+nicotine: 31.5±1.3; methOEA 10 mg/kg+nicotine: 33.8±4.2; MK886+vehicle+saline: 32.5±3.2; MK886+methOEA 10 mg/kg+nicotine: 30.4±3.3; Fig. 5E; vehicle+cocaine:34.9±5.8; cocaine+WY14643: 36.6±5.4).
