samples from more populations, there can also be improvements in the manner in which variant frequencies and linkage disequilibrium are handled in polygenic scoring studies. The results presented here provide benchmarks for the performance of polygenic scores in diverse populations, relative to performance in populations of European ancestry. This is important, because it not only informs power calculations for future research, but also highlights relative differences in predictive utility across diverse populations, which must be considered in public health and medical decisions regarding how and when to use polygenic risk scores.
