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Chunk #5 — MATERIALS AND METHODS — Selection of Candidate Genes

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Convergence of genome-wide association and candidate gene studies for alcoholism.
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The HuGE Navigator was developed using PubMed abstracts as the core data source and using data and text mining algorithms to develop a knowledge database (Yu et al., 2008). Each week since 2001, articles are systematically deposited in the database and represent a comprehensive list of recent articles. An automatic literature program screens PubMed for abstracts and then a genetic epidemiologist selects abstracts meeting inclusion criteria and indexes them. Phenopedia of the HuGE Navigator gives a disease-centered view of genetic association studies by providing information about genes studied in relation to a queried phenotype (Yu et al., 2010). Phenopedia was queried in July 2011 for Alcoholism and 584 genes were retrieved.