The associations between AFD and most dependence criteria remained significant after adjustment for all covariates. AFD showed a significant linear trend with withdrawal and drinking more/longer than intended. The associations with time spent drinking and continued drinking despite adverse physical/psychological effects were significant for individuals who started drinking at ages 15-17 but not for those who started drinking at ages <15. However, when all AFD <18 were combined, the associations with these two criteria were significant relative to initiation of drinking at ages 18 or older (OR = 1.34 and 1.27, data not shown) and no meaningful differences were lost by combining the two categories. In the case of activities given up because of drinking, there was a strong and significant association limited to initiation of drinking at <15 years of age (OR = 1.85).
