investigators [11]. Cerebellar slices have also been used to assess the effect of ethanol on the excitability of Purkinje cells which are innervated by cerebellar climbing fibers to evoke complex spikes [12]. At a low dose, ethanol (10mM) has been demonstrated to decrease the area of the complex spike. Diaz and Valenzuela [13] found that 20mM ethanol increased sIPSC frequency in cerebellar granule neurons from very young animals (pre-weaning), but this concentration had no effect on tonic inhibition in these cells.
