Chunk #28 — Overarching Issues — Specifiers — Course
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The extenuating circumstance “in a controlled environment” was unchanged from DSM-IV. DSM-IV also included “on agonist therapy” (e.g., methadone or unspecified partial agonists or agonist/antagonists). To update this category, DSM-5 replaced it with “on maintenance therapy” and provided specific examples.