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Chunk #31 — Discussion

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.
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We performed cis-eQTL, trans-eQTL and eQTS analyses in 31,684 blood samples - a six-fold increase in sample size over earlier studies5,9. Of the genes expressed in blood, 88.2% showed a cis-eQTL effect, 32% showed a trans-eQTL effect and 13% showed an eQTS effect.