Chunk #3 — Methods

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An efficient genome-wide association test for multivariate phenotypes based on the Fisher combination function.

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Let Xi(=0,1,2) be the number of reference alleles corresponding to a candidate SNP and Yi=(Yi1,…,Yim)′ be the measures of multiple phenotypes for the individual i. In this study, we conduct a comprehensive review of existing statistical methods that can be used to test the association between Xi and Yi.