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Chunk #5 — Introduction

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Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls.
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Cortical thickness (CT) was studied as a developmentally sensitive (Raznahan et al., 2010) sMRI index of cortical structure that can be mapped at high-spatial resolution and is well established to vary in a regionally specific manner according to genetic (Lenroot et al., 2009; Rimol et al., 2010; Shaw et al., 2009), cognitive (Shaw et al., 2006) and pathological influences (Gogtay et al., 2007; Greenstein et al., 2006).