Chunk #17 — Results — Latent Causal Variable Analysis.

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Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.

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0.95 ± 0.03), anxiety symptoms (loading = 0.92 ± 0.03), and posttraumatic stress disorder (loading = 0.92 ± 0.04). Factor 2 represented externalizing phenotypes with major contributions from risky behavior (loading = 0.85 ± 0.03) and cannabis use disorder (loading = 0.77 ± 0.04). Factor 3 represented educational attainment (loading = 0.99 ± 0.03) and cognitive performance (loading = 0.68 ± 0.03). MDD-META (DEP, Figure 4, Supplementary File 3) loaded onto factor 1 and, less strongly, on factor 2, independent of its covariance with all other phenotypes (DEP loading on Factor 1 = 0.77 ± 0.02; DEP loading on Factor 2 = 0.14 ± 0.02).