causal variants are perfectly correlated, differences in strengths of selection between ancestries might have a negligible impact on the RA of PGS. As a consequence, we can expect differences in strengths of selection between ancestries to mainly impact the term \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\rho _b^2h_2^2/h_1^2$$\end{document}ρb2h22/h12 in Eq. (1). Note, however, that our simulations were based on observed contemporary LD differences between ancestries, which have likely already been shaped by negative selection. This limitation may have masked an additional contribution of differential selection between ancestries.
