The polygenic nature of addiction has implications for the manner in which genetic predictors may eventually be used in treatment and genetic counseling. The loci detected so far, including CHRNA5 Asp398Asn, which has a verified role in smoking, have little predictive value. However, as more genetic risk variants for addiction are discovered and personalized genotyping and sequencing become widespread, there will be increased efforts to use multilocus genetic risk scores to predict vulnerability.20
