We observed no evidence for association at the whole-genome level of statistical significance between individual rare or common variants and either psychiatric illness or cognition. This is consistent with recent findings,74 which suggest that much larger samples would be required to detect such associations. Burden analysis of multiple rare and/or deleterious putative functional variants also failed to show association with these traits. We do report both functional and putative regulatory variants that are both individually, and by functional classification, nominally associated with rMDD and/or cognitive ability at the locus-wide level of significance.
