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Chunk #3 — INTRODUCTION

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Relationships between impulsivity and subjective response in an IV ethanol paradigm.
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Impulsivity has also been recognized as a risk factor for problem drinking and a possible alcohol dependence endophenotype (Dick et al. 2010). In multiple studies, impulsivity has been related to alcohol use (Sher and Trull 1994; Verdejo-Garcia et al. 2008), alcohol-related problems (Littlefield et al. 2010) and dependence (Bjork et al. 2004). Genetic studies have concluded that impulsivity and related constructs (e.g., conduct disorder) share a common genetic liability with alcohol and other substance use disorders (Kendler et al. 2003; Krueger et al. 2002; Young et al. 2000). Thus, while they are distinct constructs, impulsivity and subjective response to alcohol may each be manifestations of genetic risk for alcohol dependence.