We found that rs4583255[T] was associated with increased expression in adult brain and blood of MAPK3, one of the 16p11.2 genes identified as involved in causing head circumference changes in zebrafish49. Caution is required in interpretation of this result, however, as the significance in brain is marginal, and, furthermore, gene expression in the pre-adult brain may be most relevant for the development of psychosis. Data from only extremely small numbers of European-ancestry brains at pre-adult stages were available; thus, investigation of the association of rs4583255[T] with gene expression at these stages was precluded.
