main haplotype effect can be partitioned into two significant haplotype-specific associations (Table 2) with both a susceptibility effect for high dependence in the early onset group for haplotype HA (odds ratio (OR) 1.50, 95% CI 1.21 to 1.86, P = 1.3×10−4), and a protective effect for haplotype HC (OR 0.66, 95% CI 0.52 to 0.85, P = 1.1×10−3). Importantly, haplotype HB shows no significant association (OR 0.93, 95% CI 0.76 to 1.14, P = 0.50), suggesting that the two haplotype-specific associations are the result of distinct susceptibility (HA) and protective (HC) haplotype effects in the early onset group.
