assessed DNA damage markers across striatal cell types of rhesus macaques following chronic opioid administration (~6 months of twice daily opioid administration). Notably, DNA damage markers were significantly elevated across striatal neurons in opioid-exposed rhesus macaques, further implicating neuronal generated DNA damage response in response to chronic opioid use5,7,29–33. We also explored the interaction between OUD and sex, finding both sex-specific and cell type-specific molecular alterations in the dorsal striatum of individuals with OUD. As a resource, the filtered and annotated snRNA-seq datasets for human caudate and putamen in unaffected individuals and individuals with OUD are deposited on CZ CELLxGENE Discover Portal.
